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The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation.
- Source :
-
The Biochemical journal [Biochem J] 1995 Feb 01; Vol. 305 ( Pt 3), pp. 1027-30. - Publication Year :
- 1995
-
Abstract
- Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just before and during the menstrual period. This clear-cut correlation and the inhibition of collagenase expression by progesterone and oestradiol in tissue culture point to a pivotal role of this proteinase in the mechanism of menstrual tissue breakdown and bleeding.
- Subjects :
- Blotting, Northern
Collagenases metabolism
Extracellular Space enzymology
Female
Humans
Organ Culture Techniques
RNA, Messenger metabolism
Collagenases genetics
Endometrium metabolism
Estradiol pharmacology
Gene Expression Regulation drug effects
Menstruation physiology
Progesterone pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0264-6021
- Volume :
- 305 ( Pt 3)
- Database :
- MEDLINE
- Journal :
- The Biochemical journal
- Publication Type :
- Academic Journal
- Accession number :
- 7848264
- Full Text :
- https://doi.org/10.1042/bj3051027