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Measles seroprevalence and vaccine response in HIV-infected adults.
- Source :
-
Vaccine [Vaccine] 1994 Oct; Vol. 12 (13), pp. 1222-4. - Publication Year :
- 1994
-
Abstract
- Measles in HIV-infected patients can be a severe, even fatal, illness. The prevalence of measles seropositivity in HIV-infected adults and the durability of these antibody levels are uncertain. A prospective survey of 210 HIV-infected adults found that 95% of the adults had demonstrable antibodies using a standard ELISA technique. Seropositivity was no different in patients with CD4 counts over 400, from those with more advanced disease and CD4 counts under 200 (p = 0.8). Six seronegative patients were vaccinated and had serial antibody determinations: two of six (33%) patients had a durable positive antibody response at 1 year, and none had any observed toxicity. Vaccination of the identified measles-seronegative HIV-infected adults who are at high risk for measles is recommended, but a measurable antibody response may be expected in only a minority of cases.
- Subjects :
- AIDS-Related Opportunistic Infections complications
AIDS-Related Opportunistic Infections immunology
AIDS-Related Opportunistic Infections prevention & control
Adult
Cohort Studies
Female
HIV Infections complications
Humans
Male
Measles complications
Measles immunology
Measles prevention & control
Measles Vaccine immunology
Prospective Studies
Antibodies, Viral blood
HIV Infections immunology
Measles Vaccine pharmacology
Measles virus immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0264-410X
- Volume :
- 12
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 7839728
- Full Text :
- https://doi.org/10.1016/0264-410x(94)90247-x