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[Absolute and relative bioavailability of germanium in the rabbit].

Authors :
Anger FS
Anger JP
Sado PA
Chevanne F
Source :
Journal de pharmacie de Belgique [J Pharm Belg] 1994 Sep-Oct; Vol. 49 (5), pp. 395-401.
Publication Year :
1994

Abstract

The debated consumption of germanium suggested the authors to compare biopharmaceutical parameters of germanium oxide and germanium sesquioxide. A first evaluation, in rabbit, has been based on Germanium blood levels determined by atomic absorption spectrometry, after cross administration of both products by the I.V. and oral routes. When given orally, the apparent oxide bioavailability is very low (about 10%) but better than that of the sesquioxide. That difference could result from differences of disposition parameters of both products, which have to be studied late.

Details

Language :
French
ISSN :
0047-2166
Volume :
49
Issue :
5
Database :
MEDLINE
Journal :
Journal de pharmacie de Belgique
Publication Type :
Academic Journal
Accession number :
7837032