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d-Fenfluramine and d-norfenfluramine hypophagias do not require increased hypothalamic 5-hydroxytryptamine release.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1994 Oct 13; Vol. 264 (1), pp. 111-5. - Publication Year :
- 1994
-
Abstract
- d-Fenfluramine (2.5 mg/kg i.p.) caused marked hypophagia in food-deprived rats and significantly increased medial hypothalamic extracellular 5-hydroxytryptamine (5-HT) as indicated by in vivo microdialysis. When the drug was given after the 5-HT synthesis inhibitor p-chlorophenylalanine (150 mg/kg per day x 3) the hypophagic response was unimpaired but dialysate 5-HT concentration no longer rose. The d-fenfluramine metabolite d-norfenfluramine (1.5 mg/kg i.p.) caused slightly greater hypophagia than the parent drug and completely blocked feeding in animals pretreated with p-chlorophenylalanine, but dialysate 5-HT was increased in neither circumstance. The results provide evidence against mediation of the hypophagic effects of d-fenfluramine and d-norfenfluramine by increased availability of 5-HT to receptors.
- Subjects :
- Animals
Eating
Feeding and Eating Disorders metabolism
Fenclonine pharmacology
Hypothalamus drug effects
Male
Microdialysis
Rats
Rats, Sprague-Dawley
Receptors, Serotonin metabolism
Feeding and Eating Disorders chemically induced
Fenfluramine pharmacology
Hypothalamus metabolism
Norfenfluramine pharmacology
Serotonin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 264
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7828639
- Full Text :
- https://doi.org/10.1016/0014-2999(94)90646-7