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Mechanisms modifying glucose oxidation in diabetes mellitus.
- Source :
-
Diabetologia [Diabetologia] 1994 Sep; Vol. 37 Suppl 2, pp. S155-61. - Publication Year :
- 1994
-
Abstract
- The Glucose Fatty Acid Cycle as formulated 30 years ago and reviewed in the Minkowski lecture in 1966 described short term effects of fatty acids (minutes) to decrease uptake, glycolysis and oxidation of glucose in heart and skeletal muscles. Such short term effects have since been extended to include inhibition of glucose uptake and glycolysis and stimulation of gluconeogenesis in liver and these effects have also been convincingly demonstrated in man in vivo. More recently a longer term effect of fatty acid metabolism to decrease glucose oxidation (hours) has been shown in heart and skeletal muscle and liver. This effect increases the specific activity of pyruvate dehydrogenase kinase, which in turn results in enhanced phosphorylation and inactivation of the pyruvate dehydrogenase complex. Activity of the pyruvate dehydrogenase complex is the major determinant of glucose oxidation rate. It seems likely that longer term effects of fatty acids on this and other aspects of glucose metabolism could be important in the development of insulin resistance in diabetes mellitus in man.
- Subjects :
- Animals
England
Europe
Fatty Acids metabolism
Gluconeogenesis
Glycolysis
History, 20th Century
Humans
Liver metabolism
Models, Biological
Muscles metabolism
Oxidation-Reduction
Protein Kinases metabolism
Protein Serine-Threonine Kinases
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
Societies, Medical
Awards and Prizes
Diabetes Mellitus history
Diabetes Mellitus metabolism
Glucose metabolism
Pyruvate Dehydrogenase Complex metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0012-186X
- Volume :
- 37 Suppl 2
- Database :
- MEDLINE
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 7821731
- Full Text :
- https://doi.org/10.1007/BF00400839