Back to Search
Start Over
Accumbens D2 modulation of sensorimotor gating in rats: assessing anatomical localization.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 1994 Sep; Vol. 49 (1), pp. 155-63. - Publication Year :
- 1994
-
Abstract
- The normal reduction in acoustic startle amplitude caused by a weak prepulse (prepulse inhibition; PPI) is deficient in schizophrenic patients and in rats after systemic or intraaccumbens treatment with the D2 dopamine agonist quinpirole. We examined the anatomical substrates of the PPI-disruptive effects of intraaccumbens quinpirole. PPI was significantly reduced in a dose-dependent manner by quinpirole infusion into the medial accumbens shell region, the lateral accumbens core region, and an intermediate central region. There was a weak tendency for this quinpirole effect to be more pronounced in core and central accumbens regions than in the medial and anteromedial accumbens. Using the retrograde tracer Nuclear yellow, shell and core regions were verified to receive different patterns of limbic cortical innervation. Although the accumbens appears to have a complex and functionally diversified intrinsic anatomy, the accumbens D2 modulation of sensorimotor gating appears to be distributed across several different accumbens subregions.
- Subjects :
- Acoustic Stimulation
Animals
Benzimidazoles
Dopamine Agonists pharmacology
Dose-Response Relationship, Drug
Ergolines pharmacology
Fluorescent Dyes
Limbic System anatomy & histology
Limbic System drug effects
Limbic System physiology
Male
Neurons, Afferent drug effects
Neurons, Afferent physiology
Nucleus Accumbens anatomy & histology
Quinpirole
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2 drug effects
Reflex, Startle drug effects
Nucleus Accumbens physiology
Receptors, Dopamine D2 physiology
Reflex, Startle physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0091-3057
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 7816867
- Full Text :
- https://doi.org/10.1016/0091-3057(94)90470-7