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bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.
- Source :
-
Cancer research [Cancer Res] 1995 Jan 15; Vol. 55 (2), pp. 354-9. - Publication Year :
- 1995
-
Abstract
- Transgenic mice homozygously lacking in the bcl-2 gene were generated using homologous recombination in embryonal stem cells. The complete absence of Bcl-2 alpha and -beta proteins did not interfere with normal embryonic development. Abnormalities became evident after birth, although the severity varied among homozygous null mice, bcl-2-/- mice displayed pleiotropic abnormalities similar to those in the previously described bcl-2-/- mice, including growth retardation, smaller ears, short lives, polycystic kidney, atrophic thymus and spleen with accelerated apoptotic cell death of lymphocytes, and hair hypopigmentation in the second hair follicle cycle. Our bcl-2-/- mice also revealed novel defects in the small intestine, characterized by retarded development, accelerated exfoliation of epithelial cells, and very few mitotic progenitor cells.
- Subjects :
- Animals
Female
Intestine, Small pathology
Male
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Transgenic
Phenotype
Polycystic Kidney Diseases pathology
Proto-Oncogene Proteins genetics
Proto-Oncogene Proteins c-bcl-2
Spleen pathology
Thymus Gland pathology
Abnormalities, Multiple genetics
Cell Death genetics
Gene Deletion
Hair Color genetics
Intestine, Small abnormalities
Polycystic Kidney Diseases genetics
Proto-Oncogene Proteins deficiency
Spleen abnormalities
Thymus Gland abnormalities
Subjects
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 55
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 7812968