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Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1995 Jul; Vol. 172 (1), pp. 228-31. - Publication Year :
- 1995
-
Abstract
- Blood samples were obtained from 16 hemophiliacs who had a 50%-94% defined risk of human immunodeficiency virus (HIV) type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by the polymerase chain reaction. Peripheral blood cells from 7 seronegative hemophiliacs at highest risk of seroconversion (94%) were less susceptible to HIV-1 infection in vitro than were cells from healthy controls (P < .025, one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at moderate risk (50%-56%) of seroconversion did not differ from that of cells from controls or from high-risk hemophiliacs. Therefore, prolonged periods of seronegative HIV-1 infection are not common in this high-risk population. In addition, among hemophiliacs there may exist heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo.
- Subjects :
- Adult
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes immunology
Disease Susceptibility
Factor IX analysis
Factor VIII analysis
HIV Infections transmission
Hemophilia A blood
Hemophilia A immunology
Humans
Lymphocyte Count
Male
Polymerase Chain Reaction
Risk Factors
HIV Infections epidemiology
HIV Seronegativity
HIV Seropositivity immunology
HIV-1 genetics
HIV-1 isolation & purification
Hemophilia A complications
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 172
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7797917
- Full Text :
- https://doi.org/10.1093/infdis/172.1.228