Back to Search
Start Over
How well can quantitative 24-hour intraesophageal pH monitoring distinguish various degrees of reflux disease?
- Source :
-
Digestive diseases and sciences [Dig Dis Sci] 1995 Jun; Vol. 40 (6), pp. 1317-24. - Publication Year :
- 1995
-
Abstract
- Twenty-four normal subjects and 64 symptomatic patients with various degrees of reflux disease (24 with reflux symptoms without esophagitis and 21 with mild and 19 with severe esophagitis) underwent quantitative 24-hr intraesophageal pH monitoring. Various reflux parameters during supine, interprandial, and postprandial periods were examined by binary logistic regression and by CART analysis to determine the sensitivity and specificity to separate the various groups of subjects and patients. The distinction was excellent between asymptomatic controls and patients with severe erosive esophagitis (sensitivity and specificity both 100% by logistic regression and 95% and 88%, respectively, by CART), but discrimination was poor when asymptomatic controls were compared to symptomatic patients without esophagitis (71% and 79% by logistic regression and 75% and 92% by CART), which is the most important indication for pH recording in clinical practice. A 3-hr postprandial pH recording was inadequate to distinguish the various groups. The acidity of the reflux episodes during the night appeared to be a crucial factor in the development of severe erosive esophagitis. The duration of esophageal acid exposure was another important factor in the development of reflux lesions.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Esophagoscopy
Female
Gastroesophageal Reflux physiopathology
Humans
Hydrogen-Ion Concentration
Logistic Models
Male
Middle Aged
Monitoring, Physiologic instrumentation
Monitoring, Physiologic methods
Monitoring, Physiologic statistics & numerical data
Multivariate Analysis
Sensitivity and Specificity
Circadian Rhythm physiology
Esophagus physiopathology
Gastroesophageal Reflux diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0163-2116
- Volume :
- 40
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Digestive diseases and sciences
- Publication Type :
- Academic Journal
- Accession number :
- 7781454
- Full Text :
- https://doi.org/10.1007/BF02065545