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Severe hepatotoxicity related to benzarone: a report of three cases with two fatalities.
- Source :
-
Liver [Liver] 1995 Feb; Vol. 15 (1), pp. 25-9. - Publication Year :
- 1995
-
Abstract
- We report three cases of severe hepatotoxicity related to benzarone, a benzofuran derivative. Our cases include a 35-year-old woman with (sub)fulminant hepatitis, a 67-year-old woman with macronodular cirrhosis, and a 68-year-old man with severe chronic active hepatitis and cirrhosis, with positivity of anti-smooth muscle antibodies. Two patients died. We stress the potential of benzarone to cause hepatotoxicity, which usually resembles severe chronic active hepatitis. Our cases constitute the most severe cases of benzarone hepatotoxicity reported so far, and comprise the first cases of (sub)fulminant hepatitis and cirrhosis related to benzarone.
- Subjects :
- Adult
Aged
Benzbromarone administration & dosage
Benzbromarone adverse effects
Biopsy
Chemical and Drug Induced Liver Injury, Chronic
Fatal Outcome
Female
Fibrinolytic Agents administration & dosage
Hepatic Encephalopathy pathology
Hepatitis, Chronic pathology
Humans
Liver drug effects
Liver pathology
Liver Cirrhosis chemically induced
Liver Cirrhosis pathology
Male
Thrombophlebitis drug therapy
Thrombophlebitis pathology
Venous Insufficiency drug therapy
Venous Insufficiency pathology
Benzbromarone analogs & derivatives
Chemical and Drug Induced Liver Injury pathology
Fibrinolytic Agents adverse effects
Hepatic Encephalopathy chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0106-9543
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Liver
- Publication Type :
- Academic Journal
- Accession number :
- 7776854
- Full Text :
- https://doi.org/10.1111/j.1600-0676.1995.tb00102.x