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Desferrioxamine therapy accelerates clearance of iron deposits after bone marrow transplantation for thalassaemia.
- Source :
-
British journal of haematology [Br J Haematol] 1995 Apr; Vol. 89 (4), pp. 868-73. - Publication Year :
- 1995
-
Abstract
- We treated 18 heavily iron-loaded patients who had become ex-thalassaemics after bone marrow transplantation with subcutaneous desferrioxamine therapy for 5-20 months. As determined using serum ferritin concentration, transferrin saturation and stainable liver iron obtained in follow-up biopsies, marked decreases in body iron stores were observed with this regimen. Moreover, the liver function tests demonstrate a trend to normalization in all cases. Local skin reactions to desferrioxamine were the only toxicities observed. We conclude that pharmacological iron chelation is a safe and effective therapy in the reduction of iron deposits in this clinical situation; it therefore represents a valid alternative to phlebotomy in selected patients.
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 89
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 7772524
- Full Text :
- https://doi.org/10.1111/j.1365-2141.1995.tb08426.x