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The specific role of ribosomal protein S1 in the recognition of native phage RNA.
- Source :
-
European journal of biochemistry [Eur J Biochem] 1976 May 01; Vol. 64 (2), pp. 511-8. - Publication Year :
- 1976
-
Abstract
- The previously reported requirement of ribosomal protein S1 for translation of phage RNA is now shown to be related to the involvement of the protein in initiation complex formation. The structure of the messenger RNA appears to be uniquely related to S1 function, since translation and initiation and midly unfolded phage RNA (by modification with formaldehyde) are independent of S1. It is proposed that S1 functions in conjunction with initiation factor IF-3 by recognizing and unfolding elements of the tertiary structure of phage RNA. A model is suggested for S1 function in both initiation of protein synthesis and initiation of phage RNA replication.
- Subjects :
- Antigen-Antibody Reactions
Binding Sites
Formaldehyde pharmacology
Kinetics
Methionine
Nucleic Acid Denaturation
Peptide Chain Initiation, Translational
Protein Binding
RNA, Transfer metabolism
Ribosomes drug effects
Ribosomes metabolism
Temperature
Coliphages metabolism
Escherichia coli metabolism
Protein Biosynthesis drug effects
RNA, Viral metabolism
Ribosomal Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2956
- Volume :
- 64
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 776620
- Full Text :
- https://doi.org/10.1111/j.1432-1033.1976.tb10330.x