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Endotoxemia and specific antibody behavior against different endotoxins following multiple injuries.
- Source :
-
The Journal of trauma [J Trauma] 1995 May; Vol. 38 (5), pp. 794-801. - Publication Year :
- 1995
-
Abstract
- The aim of this study was to establish the incidence of endotoxemia and the influence of endotoxin on specific antibody response after multiple injury. Blood samples were collected from 39 patients (median Injury Severity Score: 20.5) at 0-3 and 6-12 hours, and 1, 3, 5, and 10 days after admission. The endotoxin plasma levels were high at the first time point (mean = 0.421 endotoxin units/mL) and decreased in the later course. Total immunoglobulin levels of IgM, IgG, or IgA were low and increased throughout the observation period. Specific antibodies of the IgM class against two lipid A and four lipopolysaccharide preparations increased transiently but significantly on day 3 and/or day 5. No changes of specific antibody content against endotoxin or lipid A was seen in the IgG or IgA class. The specific antibody content of the different classes against alpha-hemolysin of Staphylococcus aureus did not differ during 10 days after trauma. The specific antibodies of the IgM class reacted with all lipid A and LPS lipopolysaccharide preparations demonstrating cross-reactivity. These results suggest that endotoxin may be a specific stimulator of IgM antiendotoxin antibody secretion following trauma.
- Subjects :
- Adolescent
Adult
Aged
Bacterial Toxins immunology
Female
Hemolysin Proteins immunology
Humans
Immunoglobulins analysis
Lipid A immunology
Lipopolysaccharides immunology
Male
Middle Aged
Multiple Trauma blood
Antibodies, Bacterial analysis
Endotoxins blood
Endotoxins immunology
Multiple Trauma immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-5282
- Volume :
- 38
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of trauma
- Publication Type :
- Academic Journal
- Accession number :
- 7760411
- Full Text :
- https://doi.org/10.1097/00005373-199505000-00020