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Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of calbindin D-28K immunoreactivity in the cerebellar cortex of aged rats.
Effect of treatment with the dihydropyridine-type calcium antagonist darodipine (PY 108-068) on the expression of calbindin D-28K immunoreactivity in the cerebellar cortex of aged rats.
- Source :
-
Mechanisms of ageing and development [Mech Ageing Dev] 1995 Jan 13; Vol. 77 (3), pp. 149-57. - Publication Year :
- 1995
-
Abstract
- The influence of long term treatment with the dihydropyridine-type Ca2+ antagonist darodipine (PY 108-068) on age-dependent changes in calbindin D-28K immunoreactivity in the cerebellar cortex of male Wistar rats was assessed. In 12-month-old rats used as an adult reference group, specific calbindin D-28K immunoreactivity was found within the cytoplasm of Purkinje neurons and their dendritic processes. The number of Purkinje neurons displaying calbindin D-28K immunoreactivity was decreased in the cerebellar cortex of aged in comparison with adult rats. The pattern of calbindin D-28K immunoreactivity was similar in the cerebellar cortex of 24-month-old rats (aged), although a significant decrease in the intensity of immunoreactivity was noticeable. Treatment of aged rats with darodipine for 6 months increased the percentage of immunoreactive Purkinje neurons and the intensity of calbindin D-28K immunoreactivity in the cytoplasm of Purkinje neurons. Calbindin D-28K is a Ca2+ binding protein probably involved in the modulation of Ca2+ homeostasis. The observation of a positive effect of darodipine treatment on calbindin D-28K immunoreactivity in the cerebellar cortex suggests that manipulation of dihydropyridine-type Ca2+ channels may contribute to counter age-dependent changes of Ca2+ homeostasis.
- Subjects :
- Animals
Calbindins
Calcium Channel Blockers pharmacology
Immunohistochemistry
Male
Molecular Weight
Nerve Tissue Proteins metabolism
Nifedipine pharmacology
Rats
Rats, Wistar
S100 Calcium Binding Protein G chemistry
Tissue Distribution
Aging metabolism
Cerebellar Cortex metabolism
Nifedipine analogs & derivatives
S100 Calcium Binding Protein G metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0047-6374
- Volume :
- 77
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Mechanisms of ageing and development
- Publication Type :
- Academic Journal
- Accession number :
- 7739263
- Full Text :
- https://doi.org/10.1016/0047-6374(94)01512-k