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Trial of combination of guanethidine and oxprenolol in hypertension.
- Source :
-
British medical journal [Br Med J] 1976 Apr 17; Vol. 1 (6015), pp. 933-6. - Publication Year :
- 1976
-
Abstract
- Thirteen hypertensive patients entered a double-blind crossover trial of guanethidine and oxprenolol in combination. In nine patients who completed the trial there was an additive effect on blood pressure, but the combination had a smaller effect on heart rate than was expected from the individual effects, and side effects were not increased. During treatment with oxprenolol the plasma potassium concentration rose from 3.6 mmol (mEq)/1 to 3.9 mmol (mEq)/1. No correlation was found between the plasma oxprenolol concentration and changes in blood pressure or response to injected isoprenaline, but measurements of plasma oxprenolol concentrations were of value in determining compliance with the protocol.
- Subjects :
- Blood Pressure drug effects
Clinical Trials as Topic
Drug Therapy, Combination
Female
Guanethidine adverse effects
Heart Rate drug effects
Humans
Male
Oxprenolol adverse effects
Oxprenolol blood
Placebos
Potassium blood
Serum Albumin analysis
Guanethidine therapeutic use
Hypertension drug therapy
Oxprenolol therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1447
- Volume :
- 1
- Issue :
- 6015
- Database :
- MEDLINE
- Journal :
- British medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 773486
- Full Text :
- https://doi.org/10.1136/bmj.1.6015.933