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Differences in adrenergic nerve and receptor function in dog internal thoracic, coronary and mesenteric arteries.
- Source :
-
Japanese journal of pharmacology [Jpn J Pharmacol] 1994 Dec; Vol. 66 (4), pp. 481-8. - Publication Year :
- 1994
-
Abstract
- Isolated dog internal thoracic arteries (ITA) responded to norepinephrine and phenylephrine with concentration-related contractions, which were suppressed by prazosin, but not by yohimbine. Clonidine did not contract ITA. In coronary arterial strips, norepinephrine produced a relaxation. Isoproterenol relaxed coronary arterial strips contracted with serotonin but did not alter the tone of ITA. Forskolin and beraprost, an analog of prostaglandin I2, relaxed coronary and ITA strips to a similar extent. The beta-adrenoceptor density, assayed by [3H]dihydroalprenolol binding, was markedly less in ITA than in coronary arteries. Nicotine and transmural electrical stimulation did not alter the tension of ITA. Immunohistochemical study indicated that nerve fibers containing tyrosine hydroxylase immunoreactivity were markedly less in ITA than in coronary and mesenteric arteries. These results indicate that beta-adrenoceptor function and adrenergic innervation are considerably reduced in dog ITA. Norepinephrine-induced vasocontraction appears to be mediated by alpha 1-adrenoceptors in the arteries.
- Subjects :
- Animals
Coronary Vessels drug effects
Coronary Vessels innervation
Dogs
Electric Stimulation
Female
Immunohistochemistry
In Vitro Techniques
Isometric Contraction drug effects
Male
Mesenteric Arteries drug effects
Mesenteric Arteries innervation
Muscle Contraction drug effects
Muscle Relaxation drug effects
Muscle, Smooth, Vascular physiology
Radioligand Assay
Receptors, Adrenergic drug effects
Receptors, Adrenergic, beta drug effects
Receptors, Adrenergic, beta physiology
Sympathetic Nervous System drug effects
Thoracic Arteries drug effects
Thoracic Arteries innervation
Tyrosine 3-Monooxygenase metabolism
Coronary Vessels physiology
Mesenteric Arteries physiology
Muscle, Smooth, Vascular innervation
Receptors, Adrenergic physiology
Sympathetic Nervous System physiology
Thoracic Arteries physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-5198
- Volume :
- 66
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Japanese journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7723225
- Full Text :
- https://doi.org/10.1254/jjp.66.481