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Four years' treatment of resistant acromegaly with octreotide.
- Source :
-
European journal of endocrinology [Eur J Endocrinol] 1995 Apr; Vol. 132 (4), pp. 429-32. - Publication Year :
- 1995
-
Abstract
- This study was designed to ascertain the long-term safety and efficacy profile of the somatostatin analogue octreotide as treatment of refractory acromegaly. Eight patients (aged 21-62 years) with persistent growth hormone (GH) elevation (duration 1-15 years) despite previous therapy were studied. Octreotide was given subcutaneously in increasing doses for the first year to a maximum of 500 micrograms three times daily. The dose then was reduced to 200 micrograms three times daily for the next 3 years. At annual assessments, 24-h GH profiles, insulin-like growth factor I (IGF-I) and a side-effect profile including gall-bladder ultrasound were studied. Oral glucose tolerance tests (75 g) were performed basally and after 6 months and 3 years of therapy. Haemoglobin A1 (HbA1) was also assessed. Side effects were recorded. Mean GH (+/- SEM) was 36.0 +/- 9 mU/l basally and was reduced significantly at all subsequent assessments on therapy (4-year mean, 9.4 +/- 2.1 mU/l). The IGF-I level also remained suppressed and was normalized in four of eight patients who remained on octreotide. Fasting plasma glucose and HbA1 were not changed by therapy but 2-h glucose was elevated after 6 months and 3 years (basal mean, 7.6 mmol/l (5.3-9.0 mmol/l); 3-year mean, 10.7 mmol/l (8.4-15.7 mmol/l); p < 0.05). Five patients developed gallstones and in three these had disappeared following 1 year of bile salt dissolution therapy. Octreotide continues to suppress serum GH and IGF-I long term without attenuation of effect. Gallstone formation is a major side effect.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Acromegaly blood
Adult
Cholelithiasis chemically induced
Dose-Response Relationship, Drug
Drug Resistance
Gallbladder diagnostic imaging
Gallbladder pathology
Glucose Tolerance Test
Glycated Hemoglobin analysis
Growth Hormone blood
Humans
Insulin-Like Growth Factor I analysis
Middle Aged
Octreotide adverse effects
Octreotide standards
Prospective Studies
Time Factors
Ultrasonography
Acromegaly drug therapy
Octreotide therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0804-4643
- Volume :
- 132
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- European journal of endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 7711880
- Full Text :
- https://doi.org/10.1530/eje.0.1320429