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Lithium-induced impairment of urine acidification.
- Source :
-
Kidney international [Kidney Int] 1976 Apr; Vol. 9 (4), pp. 344-50. - Publication Year :
- 1976
-
Abstract
- The purpose of this study was to clarify the means by which lithium induced a disorder of urine acidification. Rats infused with hydrochloric acid (1 mEq/kg) developed acute metabolic acidosis (blood Ph = 7.32; bicarbonate, 18 mEq/liter) with a urine pH of approximately 5.85. The addition of lithium chloride (4 mEq/kg i.p) caused an increase in the urine pH (6.38) and a further decrease in blood bicarbonate (11.0 mEq/liter). During bicarbonate loading, lithium caused the urine PCO2 to fall significantly (urine minus blood PCO2 decreased from 25.3 +/-2.8 To 14.4 +/- 2.3 mm Hg) These changes were not seen following equimolar i.p. administration of sodium chloride. Similarly, lithium administration depressed bicarbonate reabsorption by 11.1% (from 30.6 to 27.2muEq/ml of GFR) during alkali infusion, while saline caused only a 5% decrease (30.0 to 28.5muEq/ml of GFR). The combination of an increase in urine PCO2 in alkaline urine indicates that lithium produced a defect in distal nephron hydrogen ion secretion. The fall in bicarbonate reabsorption following lithium administration oculd be due to a mild hydrogen ion secretory defect located in the proximal tubule or a severe defect in the distal nephron.
- Subjects :
- Acid-Base Imbalance blood
Acid-Base Imbalance chemically induced
Acidosis urine
Acidosis, Renal Tubular urine
Animals
Bicarbonates blood
Bicarbonates metabolism
Bicarbonates urine
Glomerular Filtration Rate
Hydrogen-Ion Concentration
Kidney Tubules, Proximal drug effects
Kidney Tubules, Proximal metabolism
Male
Phosphates urine
Rats
Sodium Chloride pharmacology
Acid-Base Imbalance urine
Lithium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0085-2538
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Kidney international
- Publication Type :
- Academic Journal
- Accession number :
- 7708
- Full Text :
- https://doi.org/10.1038/ki.1976.40