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Etoposide and carboplatin in extraocular retinoblastoma: a study by the Société Française d'Oncologie Pédiatrique.
- Source :
-
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 1995 Apr; Vol. 13 (4), pp. 902-9. - Publication Year :
- 1995
-
Abstract
- Purpose: A phase II study of etoposide (VP-16) and carboplatin was performed in patients with extraocular retinoblastoma to evaluate the response rate with this drug combination.<br />Patients and Methods: Twenty patients with extraocular retinoblastoma, age 9 to 120 months, were included in a cooperative multicenter phase II study of the Société Francçaise d'Oncologie Pédiatrique (SFOP). The schedule consisted of consecutive 5-day treatment with VP-16 100 mg/m2/d and carboplatin 160 mg/m2/d.<br />Results: The response rate for the 20 patients was 85%; there were nine complete responses and eight partial responses. Hematologic toxicity was the only serious observed toxicity and was always manageable.<br />Conclusion: This combination of VP-16 and carboplatin is highly effective in extraocular retinoblastoma. The high response rate is encouraging for further evaluation of this drug combination in adjuvant chemotherapy when necessary after enucleation or in neoadjuvant chemotherapy for intraocular tumors.
- Subjects :
- Brain Neoplasms drug therapy
Brain Neoplasms secondary
Carboplatin administration & dosage
Child, Preschool
Etoposide administration & dosage
Eye Neoplasms pathology
Female
Follow-Up Studies
France
Humans
Infant
Male
Orbital Neoplasms drug therapy
Orbital Neoplasms secondary
Remission Induction
Retinoblastoma secondary
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Retinoblastoma drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0732-183X
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 7707117
- Full Text :
- https://doi.org/10.1200/JCO.1995.13.4.902