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Distribution of fibronectin-binding proteins among group A streptococci of different M types.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1995 Apr; Vol. 171 (4), pp. 871-8. - Publication Year :
- 1995
-
Abstract
- Binding of fibronectin by group A streptococci (GAS) promotes adherence to epithelial cells. The fibronectin-binding activity and the presence of prtF, a gene encoding a fibronectin-binding protein, were studied among 109 strains. Fifty-six strains of 42 different M types possessed prtF-related genes, and 89% of these strains bound fibronectin at high levels. The prtF-related genes varied in the number of repeats that constitute one of its two fibronectin-binding domains. Fifty-three strains of 21 different M types lacked prtF. Thirty-nine of these (74%), representing 13 different M types, bound fibronectin at very low levels. However, 9 (17%), of 5 different M types, bound fibronectin at high levels. The presence of prtF and the capacity to bind fibronectin correlated strongly with the M type of various strains of GAS. This correlation may suggest the existence of a relationship between fibronectin binding and the pathogenic potential of GAS.
- Subjects :
- Adhesins, Bacterial genetics
Base Sequence
DNA, Bacterial analysis
Genes, Bacterial genetics
Humans
Molecular Sequence Data
Streptococcus pyogenes classification
Streptococcus pyogenes genetics
Streptococcus pyogenes pathogenicity
Virulence
Adhesins, Bacterial metabolism
Fibronectins metabolism
Polymorphism, Restriction Fragment Length
Streptococcus pyogenes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 171
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7706813
- Full Text :
- https://doi.org/10.1093/infdis/171.4.871