[Modification of cortical and trabecular mineral density of the femur, induced by ipriflavone therapy, Clinical results after 12 months].

In order to evaluate the effects of ipriflavone therapy, a clinical and metabolic study was carried out in a group of female patients with low bone mass. In particular, mineral density of the proximal femur was measured, this being a fundamental factor for the resistance of this district. At the end of the 12-months treatment cycle, reduced plasma concentration of Bone Gla Protein and urinary hydroxyproline/creatinine ratio (indicating reduced bone resorption), and a significant increase of bone density of the femoral neck and of the trabecular substructure of Ward's triangle were found. On the whole, treatment was well tolerated.