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Altered antioxidant status and increased lipid peroxidation in children with cystic fibrosis.
- Source :
-
The American journal of clinical nutrition [Am J Clin Nutr] 1995 Apr; Vol. 61 (4), pp. 843-7. - Publication Year :
- 1995
-
Abstract
- Cystic fibrosis often combines an infectious pathology with a syndrome of malabsorption, both potentially capable of favoring the deleterious effects of reactive oxygen species. This study was a simultaneous evaluation of the main antioxidant systems dependent on micronutrients and of lipid peroxidation products in 27 children with cystic fibrosis and 17 healthy children. Plasma of cystic fibrosis patients showed very low concentrations of beta-carotene (0.30 +/- 0.2 vs 1.63 +/- 0.5 mumol/g cholesterol, P < 0.0001) and a lower activity of selenium-dependent glutathione peroxidase (263.6 +/- 42 vs 296.9 +/- 57 U/L, P = 0.028). In parallel, the higher plasma concentrations of organic hydroperoxides (171.5 +/- 54.4 vs 122.6 +/- 23.3 mumol/L, P = 0.001) and of thiobarbituric acid reactants (2.9 +/- 0.6 vs 2.4 +/- 0.3 mumol/L, P = 0.004) reflected oxidative stress in this pathology. In addition, in these patients the major substrates of lipoperoxidation were significantly lower, whether they be linoleic acid (2.26 +/- 0.8 vs 3.60 +/- 0.9 mmol/L, P < 0.0001) or arachidonic acid (0.55 +/- 0.2 vs 0.74 +/- 0.2 mmol/L, P = 0.006). These results suggested that nutritional deficiencies resulting from malabsorption could considerably amplify disorders related to toxicity of reactive oxygen species. These nutritional deficits could also be aggravated by the destruction of antioxidant compounds by the inflammatory process.
- Subjects :
- Adolescent
Adult
Carotenoids blood
Child
Cholesterol blood
Cystic Fibrosis blood
Cystic Fibrosis physiopathology
Fatty Acids, Unsaturated blood
Female
Glutathione Peroxidase blood
Humans
Malabsorption Syndromes blood
Malabsorption Syndromes metabolism
Malabsorption Syndromes physiopathology
Male
Oxidative Stress
Reactive Oxygen Species
Selenium metabolism
Superoxide Dismutase blood
Thiobarbituric Acid Reactive Substances metabolism
Vitamin A blood
Vitamin E blood
Vitamins metabolism
Zinc blood
beta Carotene
Cystic Fibrosis metabolism
Lipid Metabolism
Lipid Peroxidation physiology
Vitamins blood
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9165
- Volume :
- 61
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of clinical nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 7702029
- Full Text :
- https://doi.org/10.1093/ajcn/61.4.843