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The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response.
- Source :
-
The Journal of investigative dermatology [J Invest Dermatol] 1993 Nov; Vol. 101 (5), pp. 701-5. - Publication Year :
- 1993
-
Abstract
- As a psoriatic lesion develops at sites of previously uninvolved skin, cytokines and their subsequent induction of various adhesion molecules may play important pathophysiologic roles. To further define the cytokine network in psoriasis, biopsies were obtained from both lesional skin and lesion-free skin of individuals with psoriasis and compared to normal skin biopsies from control subjects. Each biopsy was analyzed using polymerase chain reaction for expression of cytokines and immunostaining to detect adhesion molecules. The results indicate that psoriatic lesions have a type 1 cytokine profile (i.e., interleukin[IL]-2, interferon[IFN]-gamma, and tumor necrosis factor[TNF]-alpha), without a significant component of type 2 cytokines (i.e., IL-4, IL-5, and IL-10) accompanied by aberrant expression of endothelial cell leukocyte adhesion molecule (ELAM)-1 and vascular cell adhesion molecule (VCAM)-1 on dermal endothelial cells, and ICAM-1 on epidermal keratinocytes. Four of five lesion-free biopsies from psoriatic patients had prominent cytokine mRNA expression compared with skin from normal donors (particularly TNF-alpha, IL-1 alpha, IL-1 beta, with lesser increases in IFN-gamma and granulocyte/macrophage colony-stimulating factor [GM-CSF]), which was accompanied by aberrant adhesion molecule expression in the same four samples. We conclude that a particular T-cell population producing type 1 cytokines accumulates in psoriatic lesions. In addition, clinically lesion-free skin is characterized by increased levels of various cytokine mRNAs, and aberrant adhesion molecule expression in both dermal and epidermal compartments.
- Subjects :
- Adult
Base Sequence
Cell Adhesion Molecules analysis
Cytokines genetics
Cytokines physiology
E-Selectin
Humans
Intercellular Adhesion Molecule-1
Molecular Sequence Data
Polymerase Chain Reaction
RNA, Messenger analysis
Vascular Cell Adhesion Molecule-1
Cytokines analysis
Psoriasis immunology
Skin immunology
T-Lymphocytes, Helper-Inducer physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-202X
- Volume :
- 101
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of investigative dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 7693825
- Full Text :
- https://doi.org/10.1111/1523-1747.ep12371679