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Hepatitis C virus RNA in serum of blood donors with or without elevated transaminase levels.
- Source :
-
Transfusion [Transfusion] 1993 Aug; Vol. 33 (8), pp. 629-33. - Publication Year :
- 1993
-
Abstract
- The pattern of hepatitis C virus (HCV) viremia in blood donors who are positive for antibody to HCV (anti-HCV) according to the level of transaminase activity is unclear. A polymerase chain reaction-based HCV RNA detection method was used to study two clearly defined groups of anti-HCV-positive blood donors with repeatedly normal (n = 27) and elevated (n = 17) alanine aminotransferase (ALT) levels. HCV RNA was detected in only 4 of 27 blood donors with normal ALT values and 15 of 17 with elevated ALT values. These results indicate that anti-HCV-positive blood donors with normal ALT levels constitute a heterogeneous group, as HCV viremia is detectable in only a small proportion of cases. Polymerase chain reaction should be useful in the surveillance of anti-HCV-positive blood donors with normal ALT levels, by identifying those who might benefit from further investigation and treatment.
Details
- Language :
- English
- ISSN :
- 0041-1132
- Volume :
- 33
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Transfusion
- Publication Type :
- Academic Journal
- Accession number :
- 7688157
- Full Text :
- https://doi.org/10.1046/j.1537-2995.1993.33893342742.x