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Infection of a leukemic cell line (K562) by hepatitis B virus induces cell growth inhibition.
- Source :
-
Journal of hepatology [J Hepatol] 1993 Mar; Vol. 17 (3), pp. 384-9. - Publication Year :
- 1993
-
Abstract
- Hepatitis B virus inhibits the in vitro growth of the human leukemic cell line K562; however, the mechanism of this growth inhibition is not understood. One to 12 days after exposure, viral DNA and RNA were detected in K562 cells by Southern blot and reverse-transcriptase polymerase chain reaction analyses. Virus-containing serum that was heat-inactivated failed to inhibit cell growth and no viral DNA or RNA was detected in these cells. In addition, murine monoclonal antibodies directed to hepatitis B virus surface epitopes neutralized the virus-induced growth inhibition whereas antibodies to hepatitis B virus core epitopes failed to suppress the inhibition. These results indicate that in vitro infection of K562 cells by hepatitis B virus causes inhibition of hematopoietic cell line growth.
Details
- Language :
- English
- ISSN :
- 0168-8278
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 7686195
- Full Text :
- https://doi.org/10.1016/s0168-8278(05)80222-3