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CD2 + CD19 + acute lymphoblastic leukaemia in 16 children and adults: clinical and biological features. Groupe d'Etude Immunologique des Leucémies (G.E.I.L.).
- Source :
-
British journal of haematology [Br J Haematol] 1993 Apr; Vol. 83 (4), pp. 580-8. - Publication Year :
- 1993
-
Abstract
- A small population of CD2 + CD19 + lymphoid cells have been suggested to be common lymphoid progenitors. CD2 + CD19 + biphenotypic ALL account for less than 2% of ALL. We analysed the clinical and laboratory features of a series of 16 patients with CD2 + CD19 + ALL. The incidence of tumoural syndrome was comparable to a previously published series of pre B-ALL but significantly different from that of T-ALL. The mean age of the 11 children of this series was 101 +/- 46 months, and differed significantly from that of children with pre B-ALL (P < 0.01). Complete remission was obtained for all patients except two adults. Only three relapses have been observed. Regardless of the presence of CD2 +, the 16 ALL could be classified as pre B-ALL, according to the nomenclature used by the GEIL. Nine samples could be analysed by Southern blotting. Seven had rearranged IGH genes, usually on both chromosomes. IGK rearrangement was observed in three cases. Only one case had rearranged both TCRG and TCR beta. The patterns observed here and those reported previously follow that of the pre B-ALL which confirms the engagement of most CD2 + CD19 + biphenotypic ALL in the B-lineage.
- Subjects :
- Adult
Antigens, CD19
Blotting, Southern
CD2 Antigens
Child
Follow-Up Studies
Gene Rearrangement
Gene Rearrangement, T-Lymphocyte
Genes, Immunoglobulin
Humans
Immunophenotyping methods
Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Antigens, CD analysis
Antigens, Differentiation, B-Lymphocyte analysis
Antigens, Differentiation, T-Lymphocyte analysis
Precursor Cell Lymphoblastic Leukemia-Lymphoma immunology
Receptors, Immunologic analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1048
- Volume :
- 83
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 7686033
- Full Text :
- https://doi.org/10.1111/j.1365-2141.1993.tb04694.x