Neuroleptics and the immune system.

The authors investigated immunological parameters during treatment with risperidone and recorded a reduction of IgG and IgM after 24 weeks of treatment. With this finding corresponded a reduced IgG synthesis, but not IgM synthesis, investigated in vitro. It was thus revealed that risperidone does not exert an immunological effect. In the course of treatment changes of immune parameters were recorded which can be, however, explained by immunological aspects of the course of the disease. The role of the antagonist of 5HT receptors is very complicated and cannot be explained by a single mechanism.