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Effect of phospholipids on the activity of DNA polymerase I from E. coli.

Authors :
Novello F
Muchmore JH
Bonora B
Capitani S
Manzoli FA
Source :
The Italian journal of biochemistry [Ital J Biochem] 1975 Nov-Dec; Vol. 24 (6), pp. 325-34.
Publication Year :
1975

Abstract

Sphingomyelin, phosphatidylethanolamine and lecithin at concentrations which destabilize the DNA helix enhance the DNA polymerase activity, but sphingosine and phosphatidylserine have only a moderate effect. MgCl2 was shown to modify the action of sphingomyelin on the DNA polymerase activity. The role of phospholipids in the DNA replicating process was analyzed.

Subjects

Subjects :
Enzyme Activation drug effects
Escherichia coli drug effects
Kinetics
Magnesium pharmacology
Phosphatidylethanolamines pharmacology
Sphingomyelins pharmacology
DNA Nucleotidyltransferases metabolism
Escherichia coli enzymology
Phospholipids pharmacology

Details

Language :
English
ISSN :
0021-2938
Volume :
24
Issue :
6
Database :
MEDLINE
Journal :
The Italian journal of biochemistry
Publication Type :
Academic Journal
Accession number :
767289

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