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Deliberate overdose with the novel anticonvulsant tiagabine.
- Source :
-
Seizure [Seizure] 1995 Jun; Vol. 4 (2), pp. 155-7. - Publication Year :
- 1995
-
Abstract
- Tiagabine is a novel antiepileptic drug which acts by decreasing gamma aminobutyric acid uptake in astrocytes and neurones. Here the first case of deliberate overdose with this compound in a patient on concomitant phenytoin is reported. On admission to hospital his conscious level deteriorated to grade III coma. No changes in the electrocardiogram were noted. Recovery from the initial effects was rapid, and there were no sequelae. Plasma levels of tiagabine (3.1 micrograms/ml) 4 hours after ingestion were 30 times higher than at typical steady state during therapeutic dosing. The effects of poisoning with current first-line antiepileptic drugs are reviewed. The newer agents, particularly those with greater biochemical specificity, may be safer in overdose than the more established anticonvulsants.
- Subjects :
- Adult
Anticonvulsants administration & dosage
Anticonvulsants pharmacokinetics
Drug Therapy, Combination
Epilepsy, Complex Partial blood
Humans
Male
Metabolic Clearance Rate physiology
Nipecotic Acids administration & dosage
Nipecotic Acids pharmacokinetics
Phenytoin administration & dosage
Phenytoin pharmacokinetics
Tiagabine
Anticonvulsants poisoning
Epilepsy, Complex Partial drug therapy
Nipecotic Acids poisoning
Subjects
Details
- Language :
- English
- ISSN :
- 1059-1311
- Volume :
- 4
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Seizure
- Publication Type :
- Academic Journal
- Accession number :
- 7670769
- Full Text :
- https://doi.org/10.1016/s1059-1311(95)80098-0