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Induction of malformations by X-ray exposure of various stages of the oogenesis of mice.
- Source :
-
Mutation research [Mutat Res] 1995 Sep; Vol. 331 (1), pp. 119-25. - Publication Year :
- 1995
-
Abstract
- We studied the effects of ionizing radiation (X-rays, 0-3 Gy, dose rate 1 Gy/min) on various stages of oogenesis of a mouse strain (HLG/Zte) that had been shown previously to respond with an increased number of malformations after radiation exposure of preimplantation stages. Like the results obtained with preimplantation stages, we observed a statistically significant increase in the number of malformed fetuses (exclusively gastroschises) on day 19 of gestation, when oocytes within 1-4 weeks before ovulation were exposed to 2 or 3 Gy. Less mature oocytes were killed by radiation doses of 0.5 Gy and higher. In addition to the increased frequency of malformations, we found a dose-dependent increase of lethal effects (affecting either oocytes or specific gestational stages) and of runts ('dwarfs').
Details
- Language :
- English
- ISSN :
- 0027-5107
- Volume :
- 331
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Mutation research
- Publication Type :
- Academic Journal
- Accession number :
- 7666859
- Full Text :
- https://doi.org/10.1016/0027-5107(95)00057-p