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Noninvasive assessment of mitoxantrone cardiotoxicity in relapsing remitting multiple sclerosis.
- Source :
-
Journal of clinical pharmacology [J Clin Pharmacol] 1995 Jun; Vol. 35 (6), pp. 627-32. - Publication Year :
- 1995
-
Abstract
- Multiple sclerosis is the most common cause of neurologic disability in young adults. Recent reports have suggested that Mitoxantrone might be a candidate for clinical trials in multiple sclerosis patients. The authors studied 20 patients with relapsing remitting multiple sclerosis to evaluate cardiac toxicity during a one-year follow-up period. Patients were divided into 2 groups: group A, mitoxantrone treated patients (cumulative dose of 96 mg/m2); group B, placebo patients. The clinical course of multiple sclerosis was assessed using the Expanded Disability Status Scale and the number of relapses during the follow-up. Each patient had an electrocardiogram and a spectral and color flow Doppler echocardiographic examination at enrollment, and 6 and 12 months later, to investigate cardiac toxicity. The mean exacerbation rate was reduced significantly in group A patients. No significant differences in the electrocardiograms or the echocardiographic parameters of systolic and diastolic function were noted between the two groups or in group A during the follow-up. Mitoxantrone treatment seems able to improve the clinical course of relapsing remitting multiple sclerosis patients. It does not show any cardiac toxicity in selected patients at this dosage.
- Subjects :
- Adolescent
Adult
Double-Blind Method
Echocardiography
Electrocardiography
Female
Humans
Infusions, Intravenous
Male
Mitoxantrone administration & dosage
Mitoxantrone therapeutic use
Prospective Studies
Recurrence
Time Factors
Ventricular Function, Left drug effects
Heart drug effects
Mitoxantrone adverse effects
Multiple Sclerosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0091-2700
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 7665724
- Full Text :
- https://doi.org/10.1002/j.1552-4604.1995.tb05021.x