(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).

Subjects

Subjects :

Acetylation
Animals
Behavior, Animal drug effects
Drug Administration Schedule
Humans
Prodrugs chemistry
Protein Precursors metabolism
Pyridines chemistry
Rats
Receptors, Dopamine D1 metabolism
Receptors, Dopamine D2 metabolism
Structure-Activity Relationship
Tetrahydronaphthalenes chemistry
Prodrugs pharmacology
Pyridines pharmacology
Quinolones
Receptors, Dopamine D1 agonists
Tetrahydronaphthalenes pharmacology
Thiophenes

Details

Language :

English

ISSN :

0022-2623

Volume :

38

Issue :

18

Database :

MEDLINE

Journal :

Journal of medicinal chemistry

Publication Type :

Academic Journal

Accession number :

7658429

Full Text :

https://doi.org/10.1021/jm00018a002