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Bacteremia in children with sickle hemoglobin C disease and sickle beta(+)-thalassemia: is prophylactic penicillin necessary?
- Source :
-
The Journal of pediatrics [J Pediatr] 1995 Sep; Vol. 127 (3), pp. 348-54. - Publication Year :
- 1995
-
Abstract
- Objective: To characterize the incidence of bacteremia and its potential for progression to septicemia in children with sickle hemoglobin C disease and sickle beta(+)-thalassemia to assess the need for penicillin prophylaxis.<br />Study Design: Retrospective chart review of the frequency and natural history of bloodstream infection in such patients not receiving prophylactic penicillin therapy and followed up in a single institution.<br />Results: During more than 842 patient-years of observation in 242 patients with sickle hemoglobin C disease, 15 episodes of bacteremia occurred in nine patients. Septicemia was fatal in one patient. The overall incidence of bacteremia, 1.8 events per 100 patient-years (95% confidence limits: 0.8, 2.8) in patients with sickle hemoglobin C disease, was similar to that in hematologically normal children. One episode of bacteremia occurred in a patient with sickle beta(+)-thalassemia.<br />Conclusions: The incidence of bacteremia is not increased in young patients with sickle hemoglobin C disease and sickle beta(+)-thalassemia. Further, unlike its course in children with sickle cell anemia, it rarely evolves into life-threatening septicemia. This probably results from the maintenance of relatively intact splenic function during infancy and early childhood in patients with sickle hemoglobin C disease and sickle beta(+)-thalassemia. Prophylactic penicillin therapy may not be required in these patients.
- Subjects :
- Adolescent
Bacteremia prevention & control
Child
Child, Preschool
Humans
Incidence
Infant
Recurrence
Retrospective Studies
Risk Factors
Surveys and Questionnaires
Texas epidemiology
Anemia, Sickle Cell complications
Bacteremia epidemiology
Hemoglobin SC Disease complications
Penicillins therapeutic use
beta-Thalassemia complications
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 127
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 7658261
- Full Text :
- https://doi.org/10.1016/s0022-3476(95)70062-5