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[Hodgkin's disease in stages I and IIA. Analysis of results in a group of patients with a follow-up of at least 10 years treated at the onset of the disease with radiotherapy alone].

Authors :
Maurizi Enrici R
Falchetto Osti M
Anselmo AP
Tombolini V
Cartoni C
Scattoni Padovan F
Sbarbati S
Cavaceppi P
Biagini C
Source :
La Radiologia medica [Radiol Med] 1995 Jun; Vol. 89 (6), pp. 855-60.
Publication Year :
1995

Abstract

January, 1972, through December, 1982, ninety-four patients with Hodgkin's disease in stages I and IIA were treated in the Dept. of Radiation Oncology of the University "La Sapienza", Rome. All patients had a minimum follow-up of 10 years. After careful clinical and surgical examinations comprehensive of laparosplenectomy, all patients were submitted to extended field radiation treatment. Ninety-one of 94 patients (97%) obtained complete remission. Overall survival at 10 years was 91% and independent of stage (94% in stage I and 87% in stage II), while relapse-free survival at 10 years did depend on stage (83% in stage I and 49% in stage II); the difference was statistically significant (p < 0.01). Thirty-one of 94 patients relapsed, but fortunately 94% of them obtained a second complete remission after salvage chemotherapy. Our experience confirms the low tumorigenic potential of exclusive radiation therapy; only one of 4 secondary neoplasms (acute non-lymphatic leukemia) observed in this series had been treated with radiotherapy. The results of this study confirm the efficacy of exclusive irradiation in stage I patients, while treatment approach remains debated in stage II patients. The combination of short-time chemotherapy with curative irradiation is probably the best option to reduce both the incidence of recurrences and treatment-induced complications.

Details

Language :
Italian
ISSN :
0033-8362
Volume :
89
Issue :
6
Database :
MEDLINE
Journal :
La Radiologia medica
Publication Type :
Academic Journal
Accession number :
7644742