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Differential cellular distribution of glutamate and glutamine in the rat vestibular endorgans: an immunocytochemical study.
- Source :
-
Brain research [Brain Res] 1995 Apr 10; Vol. 676 (2), pp. 285-92. - Publication Year :
- 1995
-
Abstract
- The cellular and subcellular localization of glutamate and glutamine in the rat vestibular endorgans was studied by means of postembedding immunocytochemistry. Glutamate immunoreactivity was preferentially distributed in the hair cells, whereas glutamine immunoreactivity was enriched in supporting cells. This points to a metabolic compartmentation similar to that found in glutamatergic nerve terminals and adjacent glial processes in the central nervous system. The present immunocytochemical results are consistent with the existence of a glutamate-glutamine cycle in the vestibular sensory epithelium. Our data are also in agreement with a transmitter role of glutamate in both types of hair cell, although a vesicular enrichment of glutamate in these cells remains to be demonstrated.
Details
- Language :
- English
- ISSN :
- 0006-8993
- Volume :
- 676
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain research
- Publication Type :
- Academic Journal
- Accession number :
- 7613998
- Full Text :
- https://doi.org/10.1016/0006-8993(95)00099-c