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Differential cellular distribution of glutamate and glutamine in the rat vestibular endorgans: an immunocytochemical study.

Authors :
Usami S
Ottersen OP
Source :
Brain research [Brain Res] 1995 Apr 10; Vol. 676 (2), pp. 285-92.
Publication Year :
1995

Abstract

The cellular and subcellular localization of glutamate and glutamine in the rat vestibular endorgans was studied by means of postembedding immunocytochemistry. Glutamate immunoreactivity was preferentially distributed in the hair cells, whereas glutamine immunoreactivity was enriched in supporting cells. This points to a metabolic compartmentation similar to that found in glutamatergic nerve terminals and adjacent glial processes in the central nervous system. The present immunocytochemical results are consistent with the existence of a glutamate-glutamine cycle in the vestibular sensory epithelium. Our data are also in agreement with a transmitter role of glutamate in both types of hair cell, although a vesicular enrichment of glutamate in these cells remains to be demonstrated.

Details

Language :
English
ISSN :
0006-8993
Volume :
676
Issue :
2
Database :
MEDLINE
Journal :
Brain research
Publication Type :
Academic Journal
Accession number :
7613998
Full Text :
https://doi.org/10.1016/0006-8993(95)00099-c