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Modulation of feeding by beta 2-microglobulin, a marker of immune activation.
- Source :
-
The American journal of physiology [Am J Physiol] 1995 Jun; Vol. 268 (6 Pt 2), pp. R1513-9. - Publication Year :
- 1995
-
Abstract
- Increased levels of beta 2-microglobulin (part of the class I major histocompatibility complex molecules) in body fluids are associated with activation of the immune system and pathophysiological processes. Various anorexigenic cytokines, including interferon-gamma and tumor necrosis factor-alpha, induce the expression of class I molecules. Therefore, it is possible that beta 2-microglobulin may participate in the feeding suppression induced by cytokines or may have direct effects on feeding. In the present study, the effects of beta 2-microglobulin on the central regulation of feeding were investigated. Intracerebroventricular (ICV) microinfusion of beta 2-microglobulin (0.01-5.0 micrograms/rat) suppressed the nighttime food intake dose dependently. The most effective dose of beta 2-microglobulin, 5.0 micrograms/rat, decreased nighttime feeding by 38% and total daily food intake by 28%. Computerized analysis of behavioral patterns demonstrated that beta 2-microglobulin decreased meal size and meal frequency during the initial 4-h interval, but decreased only meal size during the second 4-h interval after the ICV microinfusion of 5.0 micrograms beta 2-microglobulin/rat; meal duration was not significantly affected in any interval. For the complete nighttime period, only meal size was significantly decreased. Cerebrospinal fluid-brain and rectal temperatures did not change significantly. ICV microinfusion of heat-treated beta 2-microglobulin or intraperitoneal administration of beta 2-microglobulin, in doses equivalent to those administered centrally, had no effect on food intake. The results suggest that beta 2-microglobulin may act centrally to decrease feeding, and this effect may participate in the anorexia frequently accompanying pathological processes.
- Subjects :
- Animals
Body Temperature Regulation drug effects
Brain
Cerebral Ventricles drug effects
Infusions, Parenteral
Injections, Intraperitoneal
Male
Rats
Rats, Wistar
Rectum
Reference Values
Time Factors
beta 2-Microglobulin administration & dosage
Cerebral Ventricles physiology
Drinking Behavior drug effects
Feeding Behavior drug effects
beta 2-Microglobulin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9513
- Volume :
- 268
- Issue :
- 6 Pt 2
- Database :
- MEDLINE
- Journal :
- The American journal of physiology
- Publication Type :
- Academic Journal
- Accession number :
- 7611528
- Full Text :
- https://doi.org/10.1152/ajpregu.1995.268.6.R1513