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[Usefulness of every-other day administration of proton pump inhibitors from the standpoint of continuous 48-hour pH measurements-- Comparison of cimetidine, omeprazole, and lansoprazole].
- Source :
-
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology [Nihon Shokakibyo Gakkai Zasshi] 1995 Jun; Vol. 92 (6), pp. 919-24. - Publication Year :
- 1995
-
Abstract
- We compared the usefulness of proton pump inhibitors (PPIs) every other day, with H2-blocker, in terms of inhibitory effect on gastric acid secretion. The dosages were as follows; cimetidine (CIM), 800mg and 400mg every day; omeprazole (OPZ) 20mg, and lansoprazole (LPZ), 30mg every other day. We continuously measured intragastric pH and calculated the time that pH was maintained at pH4 or more (pH4 holding time). The pH4 holding time as a part of total measurement time was significantly longer in the PPI every other day groups than in the H2-blocker groups, but there were no significant differences between the groups during the night. In PPI every other day groups, pH4 holding time of daytime period was suggested to be longer than on H2-blocker groups. In conclusion, their efficacy was greater than in the CIM group, and they appear to have a broad range of applications to the treatment of peptic ulcer.
- Subjects :
- 2-Pyridinylmethylsulfinylbenzimidazoles
Drug Administration Schedule
Female
Humans
Hydrogen-Ion Concentration
Lansoprazole
Male
Monitoring, Physiologic
Peptic Ulcer metabolism
Anti-Ulcer Agents administration & dosage
Cimetidine administration & dosage
Gastric Acid metabolism
Omeprazole administration & dosage
Omeprazole analogs & derivatives
Peptic Ulcer drug therapy
Proton Pump Inhibitors
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0446-6586
- Volume :
- 92
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
- Publication Type :
- Academic Journal
- Accession number :
- 7609313