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Drosophila MEF2 is regulated by twist and is expressed in both the primordia and differentiated cells of the embryonic somatic, visceral and heart musculature.
- Source :
-
Mechanisms of development [Mech Dev] 1995 Mar; Vol. 50 (1), pp. 29-41. - Publication Year :
- 1995
-
Abstract
- We describe a group of Drosophila cDNAs that encode MADs box proteins and which are members of the MEF2 (myocyte enhancer-binding factor 2) family of transcription factors. Drosophila has a single MEF2 gene, DMEF2, that is alternatively spliced to produce different transcripts and which is expressed in the mesodermal primordium before gastrulation. The mechanisms responsible for the subsequent subdivision of the mesoderm are unknown. However, DMEF2 may play a role in this important event because our experiments show that it is a downstream target for twist and that its early expression pattern modulates as the mesoderm is organising into cell groupings with distinct fates. DMEF2 is also expressed in both the segregating primordia and the differentiated cells of the somatic, visceral and heart musculature. It is the only known gene expressed in these three main types of muscle throughout differentiation.
- Subjects :
- Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Cell Differentiation physiology
Cloning, Molecular
Drosophila Proteins
Heart embryology
MEF2 Transcription Factors
Mesoderm metabolism
Molecular Sequence Data
Muscles cytology
Muscles metabolism
Myocardium cytology
Myocardium metabolism
Myogenic Regulatory Factors
Viscera embryology
Viscera metabolism
DNA-Binding Proteins genetics
Drosophila genetics
Gene Expression Regulation, Developmental physiology
Genes, Insect
Muscles embryology
Transcription Factors genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0925-4773
- Volume :
- 50
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Mechanisms of development
- Publication Type :
- Academic Journal
- Accession number :
- 7605749
- Full Text :
- https://doi.org/10.1016/0925-4773(94)00323-f