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Sensitivity and specificity of a new ELISA method for determination of chromogranin A in the diagnosis of pheochromocytoma and neuroblastoma.
- Source :
-
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 1995 Jul 31; Vol. 239 (1), pp. 57-63. - Publication Year :
- 1995
-
Abstract
- We have evaluated a new commercially available ELISA kit for determination of plasma chromogranin A with respect to its usefulness in the diagnosis of neuroendocrine tumors, mainly pheochromocytoma. Serum and differently anticoagulated plasmas gave different chromogranin A concentrations. Control values (n = 21) were 18.9 +/- 5.8 units/l. Chromogranin A values > 30.4 units/l (mean + 2 S.D.) were considered elevated. In 22 patients suspected of (but found not to have) pheochromocytoma and in 24 patients with renovascular hypertension, 18% were found to have elevated chromogranin A concentrations. In renovascular hypertension chromogranin A correlated positively with serum creatinine; chromogranin A was strongly elevated especially in chronic renal failure. In 45 patients with pheochromocytoma, 13 (29%) had chromogranin A concentrations within the normal range, as had 3 out of 11 patients with neuroblastoma (27%). In 13 pheochromocytoma patients with elevated chromogranin A, measurements were repeated after surgical removal of the tumor; values then all fell within the normal range. We conclude that measurement of chromogranin A adds little to already existing methods for the diagnosis of pheochromocytoma.
- Subjects :
- Adult
Aged
Chromogranin A
Creatinine blood
Edetic Acid
Female
Glutathione blood
Heparin
Humans
Hypertension, Renovascular blood
Kidney Failure, Chronic blood
Male
Middle Aged
Neuroblastoma blood
Pheochromocytoma blood
Plasma
Reference Values
Sensitivity and Specificity
Chromogranins blood
Enzyme-Linked Immunosorbent Assay methods
Enzyme-Linked Immunosorbent Assay statistics & numerical data
Neuroblastoma diagnosis
Pheochromocytoma diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0009-8981
- Volume :
- 239
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinica chimica acta; international journal of clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 7586587
- Full Text :
- https://doi.org/10.1016/0009-8981(95)06100-r