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Increasing development of pepsinogen-altered pyloric glands and adenocarcinoma in glandular stomach of analbuminemic rats.
- Source :
-
Cancer letters [Cancer Lett] 1995 Sep 25; Vol. 96 (2), pp. 219-24. - Publication Year :
- 1995
-
Abstract
- The susceptibility of pepsinogen-altered pyloric glands (PAPG) and neoplastic glandular stomach lesions induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and catechol or sodium cholate in Nagase analbuminemic rats (NAR) was compared to Sprague-Dawley rats (SD). Male NAR and SD rats were given a single dose of 80 mg/kg body weight of MNNG by gastric intubation and, 2 weeks later, fed basal diet containing 0.8% catechol or 0.3% sodium cholate for 18 weeks. The animals were killed at the end of week 20 or after maintenance on basal diet at week 60. The number of pepsinogen-altered pyloric glands at week 20 was significantly (P < 0.001) higher in NAR fed either catechol or sodium cholate compared with SD rats. At week 60, adenomatous hyperplasias and adenocarcinomas were observed in 7 (88%; P < 0.01) and 3 (38%; P < 0.01) of 8 NAR fed catechol and in 4 (22%) and 0 of 18 SD rats, respectively. The results show that the frequency of PAPG in NAR and SD rats is related to the susceptibility to glandular stomach carcinoma. PAPG is a useful endpoint lesion for evaluation of gastric carcinogenicity in a 20-week carcinogenicity test, and NAR are sensitive for glandular stomach carcinogenesis.
- Subjects :
- Adenocarcinoma chemically induced
Animals
Carcinogens
Cholic Acid
Gastric Mucosa enzymology
Gastric Mucosa pathology
Hyperplasia
Male
Methylnitronitrosoguanidine
Pyloric Antrum
Rats
Rats, Mutant Strains
Rats, Sprague-Dawley
Serum Albumin genetics
Species Specificity
Stomach Neoplasms chemically induced
Adenocarcinoma pathology
Catechols toxicity
Cholic Acids toxicity
Gastric Mucosa drug effects
Pepsinogens metabolism
Serum Albumin deficiency
Stomach Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3835
- Volume :
- 96
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 7585460
- Full Text :
- https://doi.org/10.1016/0304-3835(95)03935-p