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Free D-serine concentration in normal and Alzheimer human brain.
- Source :
-
Brain research bulletin [Brain Res Bull] 1995; Vol. 38 (2), pp. 181-3. - Publication Year :
- 1995
-
Abstract
- We have analyzed both free L- and D-serine in frontal cortex of normal and Alzheimer human brain by high-performance liquid chromatography (HPLC). There was no significant difference between the two brains. In normal brain, L- and D-serine concentrations were 666 +/- 222 and 66 +/- 41 nmol/g of wet tissue, respectively, and the ratio of D-isomer to L-isomer (D/L) was 0.099 +/- 0.031. In Alzheimer brain, the concentrations were 750 +/- 150 and 66 +/- 40 nmol/g, respectively, and the D/L ratio was 0.086 +/- 0.040. Thus, it was shown that the free D-serine concentration in the Alzheimer brain was comparable to that in the normal brain.
Details
- Language :
- English
- ISSN :
- 0361-9230
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Brain research bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 7583345
- Full Text :
- https://doi.org/10.1016/0361-9230(95)00087-u