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Extrapyramidal symptoms in a BMT recipient with hyperintense basal ganglia and elevated manganese.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 1995 Jun; Vol. 15 (6), pp. 989-92. - Publication Year :
- 1995
-
Abstract
- Neurologic syndromes attributed to conditioning or medications have been reported in BMT recipients. A patient is presented who developed extrapyramidal symptoms on day +56 after allogeneic BMT. Brain magnetic resonance images of this patient demonstrated hyperintense basal ganglia, which has been associated with manganese (Mn) toxicity. The patient had received total parenteral nutrition (TPN) with standard trace element supplementation and had been cholestatic. Serum Mn was elevated, and continued to be so 5 months after BMT, long after discontinuation of TPN. Cholestatic patients and those on long-term TPN have been found to have high blood or serum levels of Mn, but generally are asymptomatic. When other cholestatic BMT patients were reviewed, all had elevated serum Mn. Manganese supplementation in TPN requires evaluation for BMT recipients.
- Subjects :
- Basal Ganglia chemistry
Female
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapy
Manganese administration & dosage
Manganese blood
Manganese pharmacokinetics
Middle Aged
Basal Ganglia pathology
Bone Marrow Transplantation
Magnetic Resonance Imaging
Manganese adverse effects
Parenteral Nutrition, Total adverse effects
Parkinson Disease, Secondary chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0268-3369
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 7581103