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Relevance of 10 Caucasian HLA haplotypes in searches for unrelated bone marrow donors for 100 patients from a single center.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 1995 Jun; Vol. 15 (6), pp. 845-51. - Publication Year :
- 1995
-
Abstract
- Unrelated donor searches for 100 Caucasian patients were referred to France Greffe de Moëlle Registry (FGM) from September 1987 (24,600 donors) to December 1993 (71,500 donors, 61% DR typed). After DR typing of HLA-A,B matched donors, unsuccessful searches were extended to other European Registries for 36 patients. Twenty two patients had a donor (FGM: 19, other Registries: 3) selected on: (1) HLA-A,B and DRB,DQB1 split identity; and (2) unidirectional relative response < 5% in MLR performed twice. Estimated probability of finding a compatible donor at 9 months in FGM was 12% (s.e. +/- 4%) and 25% at 2 years (s.e. +/- 6%). This probability was stringently dependent on a phenoidentity to one very common HLA-A,B,DR or B,DR haplotype (25% at 9 months when present, representing 19 of 19 patients with a compatible donor). Without this phenoidentity, the probability was zero per cent (P = 0.0001) in FGM searches and < 4% (n = 1) in extended searches. The MLR test was shown to be insensitive for screening for DPB1 mismatches. Clinical status influenced the probability of finding a compatible donor at one year ranging from 9% +/- 9% for ALL to 23% +/- 8% for CML (NS). Disregarding DPB1 mismatches is the most efficient way of increasing search efficiency.
- Subjects :
- Europe epidemiology
France epidemiology
Gene Frequency
HLA-DP Antigens genetics
HLA-DP beta-Chains
Humans
Lymphocyte Culture Test, Mixed
Transplantation, Homologous immunology
Bone Marrow Transplantation immunology
Bone Marrow Transplantation standards
HLA Antigens genetics
Haplotypes
Registries
Tissue Donors
Tissue and Organ Procurement methods
White People genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0268-3369
- Volume :
- 15
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 7581079