Back to Search
Start Over
Genetic detoxification of bacterial toxins: a new approach to vaccine development.
- Source :
-
International archives of allergy and immunology [Int Arch Allergy Immunol] 1995 Dec; Vol. 108 (4), pp. 327-33. - Publication Year :
- 1995
-
Abstract
- Chemically detoxified bacterial toxins (toxoids) have been successfully used as vaccines for the prevention of many bacterial infectious diseases. Today, nontoxic derivatives of bacterial toxins can be obtained by mutagenesis of the toxin genes. These genetically inactivated toxins are superior to the classical toxoids both in safety and in immunogenicity and therefore they should replace the old toxoids in the existing vaccines. In addition, they represent a novel class of immunogens with unique properties, some of which may be used for innovative approaches to vaccination.
- Subjects :
- Antigen Presentation
Bacterial Toxins immunology
Cholera Toxin genetics
Cholera Toxin immunology
Diarrhea prevention & control
Enterotoxins genetics
Enterotoxins immunology
Escherichia coli Proteins
Humans
Toxoids immunology
Virulence Factors, Bordetella genetics
Virulence Factors, Bordetella immunology
Whooping Cough prevention & control
Bacterial Infections prevention & control
Bacterial Toxins genetics
Bacterial Vaccines immunology
Toxoids genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1018-2438
- Volume :
- 108
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International archives of allergy and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 7580303
- Full Text :
- https://doi.org/10.1159/000237176