Acute effect of 8-methoxypsoralen and ultraviolet light on sister chromatid exchange.

Authors :: Wulf HC
Source :: Archives of dermatological research [Arch Dermatol Res] 1978; Vol. 263 (1), pp. 37-46.
Publication Year :: 1978
Abstract: The acute effect of 8-methoxypsoralen (8-MOP) and 8-MOP + long wave ultraviolet light (UVA) on sister chromatid exchange (SCE) has been examined in an in vitro experiment. The SCE count was significantly increased by 8-MOP without light, but the effect was substantially greater (50%) by 8-MOP + UVA. In addition, mitoses with banded staining of the chromosomes were seen after 8-MOP and UVA. These changes were dose dependent, and they might be responsible for the reduced cell turnover in psoriasis plaque after PUVA.

Subjects :: Ethanol pharmacology
Humans
In Vitro Techniques
Metaphase drug effects
Metaphase radiation effects
Mitosis drug effects
Mitosis radiation effects
Sister Chromatid Exchange radiation effects
Time Factors
Crossing Over, Genetic drug effects
Methoxsalen pharmacology
Photochemotherapy
Sister Chromatid Exchange drug effects
Ultraviolet Rays

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