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A pilot study of splenic and whole body retention of autologous radiolabeled leukocytes in the assessment of severity in inflammatory colitis.
- Source :
-
The American journal of gastroenterology [Am J Gastroenterol] 1995 Oct; Vol. 90 (10), pp. 1771-5. - Publication Year :
- 1995
-
Abstract
- Objective: To assess the splenic and whole body retention of radiolabeled autologous leukocytes over 24 or 48 h as measures of the severity of colitis.<br />Methods: Eleven patients with colitis underwent standardized clinical, endoscopic, histological, and 111In-labeled leukocyte scintigraphy. A logistic discriminant analysis was used to estimate weighting factors for morphological indices, serum albumen, and stool excretion of 111In over 24 h that predicted the clinical assessment of severity. Subsequently, Spearman rank correlation analysis estimated associations among reductions in spleen and whole body radioactivity and the derived indices of inflammation.<br />Results: The reduction in spleen counts over 24 h correlates significantly with morphological indices (rs = 0.83, p < 0.005) and with serum albumen and stool 111In (functional index, rs = 0.77, p < 0.01). Similarly, the reduction in whole body 111In over 48 h correlates significantly with the combined index (rs = 0.8) and with the morphological and functional index separately (rs = 0.72 and 0.79, respectively).<br />Conclusion: This pilot study identified weighting factors for morphological and functional indices in assessing severity of colitis; reduction in whole body and splenic retention of radioactivity was sufficient for evaluation of severity of colitis without the need for stool collections.
- Subjects :
- Colitis, Ulcerative blood
Colitis, Ulcerative pathology
Colonoscopy
Crohn Disease blood
Crohn Disease pathology
Humans
Pilot Projects
Radionuclide Imaging
Serum Albumin analysis
Colitis, Ulcerative diagnostic imaging
Crohn Disease diagnostic imaging
Indium Radioisotopes
Leukocytes
Spleen diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9270
- Volume :
- 90
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The American journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 7572892