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Effect of passive antibody on congenital cytomegalovirus infection in guinea pigs.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1995 Oct; Vol. 172 (4), pp. 944-50. - Publication Year :
- 1995
-
Abstract
- Cytomegalovirus (CMV) is the most common congenital viral infection, but little is known about the protective immune mechanisms. The guinea pig (gp) model of congenital CMV was used to evaluate the effects of passive antibody given to pregnant dams on pup survival. Dams received three doses of high-titer gpCMV or control antibody on days -3, -1, and +7, or +1, +3, and +7, in relation to gpCMV challenge. gpCMV was inoculated in the late second to early third trimester at three different doses. Compared with controls, gpCMV antibody begun before gpCMV challenge significantly increased pup survival from 14% to 52%, 21% to 84%, and 51% to 77%, respectively, for the three challenge doses. gpCMV antibody started after viral challenge increased pup survival after only the lowest challenge dose (51% to 81%). Antibody did not protect against CMV infection of the pups. CMV antibody appeared to improve survival in congenital CMV infection but did not affect vertical transmission.
- Subjects :
- Animals
Animals, Newborn virology
Antibodies, Viral blood
Cytomegalovirus Infections congenital
Cytomegalovirus Infections prevention & control
Female
Guinea Pigs
Male
Pregnancy
Survival Analysis
Treatment Outcome
Antibodies, Viral administration & dosage
Cytomegalovirus Infections transmission
Cytomegalovirus Infections veterinary
Immunization, Passive
Infectious Disease Transmission, Vertical
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 172
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7561214
- Full Text :
- https://doi.org/10.1093/infdis/172.4.944