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Pediatric renal transplantation at the University of Minnesota: the cyclosporine years.
- Source :
-
Clinical transplants [Clin Transpl] 1994, pp. 203-12. - Publication Year :
- 1994
-
Abstract
- Overall mortality was low (3.5%) in 199 children who received 217 transplants and quadruple immunosuppression. Graft survival was better in patients on quadruple immunosuppression, compared with historical patients on standard immunosuppression. When censored for deaths with a functioning graft, cumulative graft survival beyond one year was significantly better in patients on quadruple immunosuppression. Acute rejection was more common in CAD recipients and in retransplant recipients. Acute rejection was also more common in patients with FSGS, compared with other causes of ESRD. Preemptive transplants were not associated with a higher incidence of acute rejection. Late acute rejection episodes tended to be associated with a CsA dose < 5 mg/kg/day at one-year posttransplant. Chronic rejection was the major cause of graft loss. Risk factors for graft loss within the first posttransplant year were acute tubular necrosis and an initial CsA dose of < 5 mg/kg/day. Risk factors for graft loss after the first posttransplant year were late onset of the first acute rejection episode and a panel reactivity of > 25% at the time of transplant.
- Subjects :
- Actuarial Analysis
Child
Child, Preschool
Demography
Female
Graft Rejection epidemiology
Hospitals, University statistics & numerical data
Humans
Immunosuppression Therapy adverse effects
Immunosuppression Therapy methods
Infant
Kidney Transplantation mortality
Kidney Tubular Necrosis, Acute epidemiology
Kidney Tubular Necrosis, Acute etiology
Male
Minnesota epidemiology
Neoplasms etiology
Neoplasms immunology
Postoperative Complications etiology
Postoperative Complications immunology
Retrospective Studies
Survival Analysis
Survival Rate
Treatment Outcome
Cyclosporine therapeutic use
Kidney Transplantation statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 0890-9016
- Database :
- MEDLINE
- Journal :
- Clinical transplants
- Publication Type :
- Academic Journal
- Accession number :
- 7547541