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Could HLA-DRB1 be the protective locus in rheumatoid arthritis?
- Source :
-
Immunology today [Immunol Today] 1995 Jun; Vol. 16 (6), pp. 274-8. - Publication Year :
- 1995
-
Abstract
- Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DR beta 1 molecule. On the basis of recent findings in the experimental mouse model of collagen-induced arthritis, Eric Zanelli, Miguel Gonzalez-Gay and Chella David propose that the HLA-DRB1 locus is associated with protection to RA and that the actual arthritogenic peptide-presenting molecule is HLA-DQ. Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.
- Subjects :
- Alleles
Animals
Antigen Presentation
Arthritis chemically induced
Arthritis genetics
Arthritis immunology
Arthritis, Rheumatoid ethnology
Arthritis, Rheumatoid immunology
Autoimmune Diseases ethnology
Autoimmune Diseases immunology
Collagen toxicity
Disease Models, Animal
Disease Susceptibility ethnology
Disease Susceptibility immunology
Diseases in Twins
Epitopes immunology
Genetic Predisposition to Disease
HLA-DQ Antigens genetics
HLA-DQ Antigens immunology
HLA-DQ beta-Chains
HLA-DR Antigens immunology
HLA-DRB1 Chains
Histocompatibility Antigens Class II immunology
Humans
Mice
Mice, Transgenic
Polymorphism, Genetic
T-Lymphocyte Subsets immunology
Arthritis, Rheumatoid genetics
Autoimmune Diseases genetics
HLA-DR Antigens genetics
Histocompatibility Antigens Class II genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0167-5699
- Volume :
- 16
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Immunology today
- Publication Type :
- Academic Journal
- Accession number :
- 7544977
- Full Text :
- https://doi.org/10.1016/0167-5699(95)80181-2