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Serum concentration of intercellular adhesion molecule-1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis.
- Source :
-
Hepatology (Baltimore, Md.) [Hepatology] 1995 Aug; Vol. 22 (2), pp. 525-31. - Publication Year :
- 1995
-
Abstract
- Serum levels of soluble forms of intracellular adhesion molecule-1 (sICAM-1) and lymphocyte function-associated antigen-3 (sLFA-3) in 122 patients with chronic liver disease including hepatocellular carcinoma (HCC) were measured by enzyme-linked immunosorbent assays. Serum levels of sICAM-1 in patients with HCC were significantly higher than those of chronic hepatitis (CH) and cirrhosis. On the other hand, serum levels of sLFA-3 in patients with HCC were almost the same as those of cirrhosis. Western blot analyses showed that molecular sizes of sICAM-1 and sLFA-3 detected in the sera were 90 kd and 50 kd, respectively, indicating that both molecules include whole extracellular domains. In patients with HCC, circulating sICAM-1 levels were significantly (P < .001) correlated with tumor volume (r = .50), total bilirubin (r = .38), serum aspartate aminotransferase levels (r = .51), and gamma-globulin (r = .63). Furthermore, serum sICAM-1 levels were significantly elevated in patients with multiple HCC (tumor number > 3) or HCC with tumor embolus in the first branch or trunk of portal vein. Survival periods were analyzed in relation to serum sICAM-1 levels in patients with HCC who had been treated by transcatheter arterial chemoembolization. The HCC patients with < 1,000 ng/mL of serum ICAM-1 showed significantly (P = .0005) longer survival than those with higher levels of the molecule. The same results were obtained when only patients with moderately differentiated HCC were analyzed (P = .02). Analyses by Cox's proportional hazard model showed that sICAM-1 is a significant (P = .032) prognostic factor for patients with HCC.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Adult
Aged
Antigens, CD blood
CD58 Antigens
Carcinoma, Hepatocellular mortality
Carcinoma, Hepatocellular pathology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Liver Neoplasms mortality
Liver Neoplasms pathology
Male
Membrane Glycoproteins blood
Middle Aged
Neoplasm Staging
Prognosis
Survival Rate
Carcinoma, Hepatocellular blood
Intercellular Adhesion Molecule-1 blood
Liver Neoplasms blood
Subjects
Details
- Language :
- English
- ISSN :
- 0270-9139
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Hepatology (Baltimore, Md.)
- Publication Type :
- Academic Journal
- Accession number :
- 7543436